Scientific Publications

Publications of the Maastricht group related to CA IX:

Dubois L, Douma K, Supuran CT, Chiu RK, van Zandvoort MA, Pastorekova S, Scozzafava A, Wouters BG, Lambin P. Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors. Radiother Oncol. 2007 Jun;83(3):367--73

Dubois L, Lieuwes NG, Maresca A, Thiry A, Supuran CT, Scozzafava A, Wouters BG, Lambin P. Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumor model. Radiother Oncol. 2009 Sep;92(3):423-8.

Dubois L, Peeters S, Lieuwes NG, Geusens N, Thiry A, Wigfield S, Carta F, McIntyre A, Scozzafava A, Dogné JM, Supuran CT, Harris AL, Masereel B, Lambin P Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.. Radiother Oncol. 2011 Jun;99(3):424-31.

Dubois L, Peeters SG, van Kuijk SJ, Yaromina A, Lieuwes NG, Saraya R, Biemans R, Rami M, Parvathaneni NK, Vullo D, Vooijs M, Supuran CT, Winum JY, Lambin P. Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs.
Radiother Oncol. 2013 Sep;108(3):523-8.

van den Beucken T, Koritzinsky M, Niessen H, Dubois L, Savelkouls K, Mujcic H, Jutten B, Kopacek J, Pastorekova S, van der Kogel AJ, Lambin P, Voncken W, Rouschop KM, Wouters BG. Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response. J Biol Chem. 2009 Sep 4;284(36):24204-12.

Akurathi V, Dubois L, Lieuwes NG, Chitneni SK, Cleynhens BJ, Vullo D, Supuran CT, Verbruggen AM, Lambin P, Bormans GM Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia. Nucl Med Biol. 2010 Jul;37(5):557-64.

Lambin P, van Stiphout RG, Starmans MH, Rios-Velazquez E, Nalbantov G, Aerts HJ, Roelofs E, van Elmpt W, Boutros PC, Granone P, Valentini V, Begg AC, De Ruysscher D, Dekker A. Predicting outcomes in radiation oncology--multifactorial decision support systems. Nat Rev Clin Oncol. 2013 Jan;10(1):27-40.

Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY. Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates.
J Med Chem. 2013 Oct 31.

Other publications related to CA IX:

  1. Ivanov, S., et al., Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol, 2001. 158(3): p. 905-19.
  2. Turner, J.R., et al., MN antigen expression in normal, preneoplastic, and neoplastic esophagus: a clinicopathological study of a new cancer-associated biomarker. Hum Pathol, 1997. 28(6): p. 740-4.
  3. Vermylen, P., et al., Carbonic anhydrase IX antigen differentiates between preneoplastic malignant lesions in non-small cell lung carcinoma. Eur Respir J, 1999. 14(4): p. 806-11.
  4. Saarnio, J., et al., Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol, 1998. 153(1): p. 279-85.
  5. Saarnio, J., et al., Transmembrane carbonic anhydrase, MN/CA IX, is a potential biomarker for biliary tumors. J Hepatol, 2001. 35(5): p. 643-9.
  6. Kivela, A.J., et al., Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumors. Histochem Cell Biol, 2000. 114(3): p. 197-204.
  7. McKiernan, J.M., et al., Expression of the tumor-associated gene MN: a potential biomarker for human renal cell carcinoma. Cancer Res, 1997. 57(12): p. 2362-5.
  8. Liao, S.Y., et al., Identification of the MN/CA IX protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res, 1997. 57(14): p. 2827-31.
  9. Hynninen, P., et al., Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumors. Histopathology, 2006. 49(6): p. 594-602.
  10. Bartosova, M., et al., Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2. J Pathol, 2002. 197(3): p. 314-21.